Please note that due to circumstances outside of anyone's control, this workshop has been cancelled. Reimbursements for attendees already registered are being processed. We are aiming to deliver this workshop in the week prior to the 31st ECCMID 2021. Good health to you all!
You are invited to an exciting workshop held in Liverpool, United Kingdom from the 14th to 16th April 2020 focused on population pharmacokinetics/pharmacodynamics modelling of antimicrobials.
This workshop is suitable for health care practitioners involved in complex drug dosing including clinical pharmacists, infectious diseases physicians, intensive care physicians, transplant physicians and clinical pharmacologists with a background in pharmacokinetic analysis. Also suitable for basic researchers including pharmacologists and translational scientists.
The 2.5 day workshop will be held In collaboration with the University of Liverpool, Laboratory of Applied Pharmacokinetics and Bioinformatics, Los Angeles and the Centre Hospitalier Universitaire de Nîmes, France.
As part of this workshop we will look at complex models including those that investigate the impact of protein binding and renal replacement therapy (dialysis) and models that explore PK changes across a lifetime, as well as optimal design methodology. Pharmacodynamic modelling will explore the effect of antimicrobial exposure on bacterial killing and emergence of resistance, immune system function and effect of combination antimicrobial therapy.
Please join us and our guest speakers and tutors from centres in the United States, Spain, France, the United Kingdom and our own Prof Jason Roberts.
Venue
40 Hope St, Liverpool L1 9DA, United Kingdom
ANTIMICROBIAL POPULATION PK/PD MODELLING AND SIMULATION
Using the Pmetrics package for R and the BestDose web-based tool
Venue: Liverpool, UK
April 14-16, 2020
Please note that due to circumstances outside of anyone's control, this workshop has been cancelled. Reimbursements for attendees already registered are being processed. We are aiming to deliver this workshop in the week prior to the 31st ECCMID 2021. Good health to you all!
Faculty & Tutors
- Prof Michael Neely, University of Southern California, USA
- Prof George Drusano, University of Florida, USA
- Prof William Hope, University of Liverpool, UK
- Dr Clement Boidin, Claude Bernard University, France
- Dr Claire Roger, CHU Nimes, France
- Dr Fernando Docobo-Perez, University of Sevilla, Spain
- Dr Catherine Byrne, Trinity College, Ireland
- Dr Suzanne Parker, The University of Queensland, Australia
- Prof Jason Roberts, The University of Queensland, Australia
Course Objectives
Using the Pmetrics package for R, users will be able to:
- Define complex pharmacokinetic (PK) and pharmacokinetic/pharmacodynamic (PK/PD) structural models.
- Analyse complex PK and PK/PD datasets (including presence of immune system, biomarker response and/or emergence of bacterial resistance).
- Perform basic Monte Carlo simulations for PK and PK/PD analysis.
With the BestDose web-based software tool, users will explore:
- Perform optimal design analyses for development of PK sampling schedules
- Application of pharmacometric methods to dose individualization
- Optimise dosing for an individual patient.
A working version of Pmetrics on all attendees laptops is required. This workshop is suitable for health care practitioners involved in complex drug dosing including clinical pharmacists, infectious diseases physicians, intensive care physicians, transplant physicians and clinical pharmacologists. Also suitable for basic researchers including pharmacologists and translational scientists.
Workshop Program
| DAY 1 Tuesday April 14 - Pharmacokinetic modelling | ||
|---|---|---|
| 1200-1300 | Lunch and Registration | |
| 1300-1330 | What's new in Pmetrics and pharmacometrics? | Prof Michael Neely |
| 1330-1400 | Review of pre-workshop tutorial | Dr Suzanne Parker |
| 1400-1500 | Modelling drug protein binding | Dr Catherine Byrne |
| 1500-1530 | Afternoon Tea | |
| 1530-1630 | Modelling complex renal replacement therapy data | Dr Clement Boidin |
| 1630-1730 | Modelling extravascular non-oral drug administration | Dr Clement Boidin |
| 1830-2130 | Networking dinner | |
| DAY 2 Wednesday April 15 - Pharmacokinetic/Pharmacodynamic modelling | ||
|---|---|---|
| 0900-1030 | Building models for your data | Tutors |
| 1030-1100 | Morning tea | |
| 1100-1130 | Pharmacodynamics (PD) principles | Dr Fernando Docobo-Perez |
| 1130-1230 | Modelling antibiotic PK/PD - monotherapy | Dr Fernando Docobo-Perez |
| 1230-1330 | Lunch | |
| 1330-1430 | Modelling antibiotic PK/PD - combination therapy | Prof Michael Neely |
| 1430-1530 | Modelling effect of immune system on bacterial killing | Prof George Drusano |
| 1530-1600 | Afternoon tea | |
| 1600-1730 | Building models for your data | Tutors |
| DAY 3 - Thursday April 16 - Optimal Design of PK Studies | |||
|---|---|---|---|
| 0900-1030 | Modelling PK with biomarker data | Prof William Hope | |
| 1030-1100 | Morning tea | ||
| 1100-1230 | Building models for your data | Tutors | |
| 1230-1330 | Lunch | ||
| 1330-1430 | Optimal design of PK studies | Prof Michael Neely | |
| 1430-1530 | Dose optimisation using BestDose | Prof Michael Neely | |
| 1530-1600 | Afternoon Tea | ||
| 1600-1730 | Dose optimisation using BestDose or Building models for your data | Prof Michael Neely | |
| 1730 | Closing | Prof Jason Roberts | |