Lyon Pmetrics Pharmacometrics Workshop
This Pmetrics workshop takes place in Lyon, France.
Organisers and sponsors:
- Laboratory of Biometrics and Evolutionary Biology, University of Lyon, France
- University Hospitals of Lyon, Lyon France
- AP2 POP association, Lyon, France
- Laboratory of Applied Pharmacokinetics and Bioinform atics, University of Southern California, Los Angeles, USA
- CRE RESPOND University of Queensland, Brisbane, Australia
Faculty:
- Michael Neely , Julian Otalvaro (USC)
- Sylvain Goutelle, Gérard Lina, Laurent Bourguignon, Romain Garreau (Lyon)
- Jean Baptiste Woillard (Limoges)
- Anne Grete Märtson (Liverpool)
- Jason Roberts, Xin Liu, Patty Mitre (UQ)
Target Audience: up to 30 physicians, pharmacists, clinical microbiologists, biomedical scientists or trainees with an interest in microbiology and pharmacology
Workshop objectives:
- Understanding the role of PK/PD in setting MIC breakpoints and associated antibiotic dosages
- Code a published population PK model into Pmetrics R package
- Run Monte-Carlo simulations with Pmetrics and analyze results for various dosage regimens
- Perform probability of target attainment (PTA) analysis for an antibiotic/bacteria couple with Pmetrics
- Identifying PK/PD breakpoints and associated standard and high dosages based on PTA analysis
- Assessing drug-related and patient-related factors influencing PTA and antibiotic dosages
TO REGISTER and secure your place email marc.grenet@univ-lyon1.fr and contact@ap2pop.org. Full registration cost is EUR500 or EUR350 for students.
Preliminary program:
Location | Local Time | Time Zone | UTC Offset |
---|---|---|---|
Brisbane (Australia – Queensland) | Thursday, 6 July 2023 6pm - Saturday, 8 July 2023 12:00 pm | AEST | UTC+10 hours |
Lyon (France – Auvergne-Rhône-Alpes) | Thursday, 6 July 2023 10am - Friday, 7 July 2023 4:00 pm | CEST | UTC+2 hours |
Liverpool (United Kingdom – England) | Thursday, 6 July 2023 9:00 am - Friday, 7 July 2023 3:00 pm | BST | UTC+1 hour |
Los Angeles (USA – California) | Thursday, 6 July 2023 8.30am - Friday, 7 July 2023 7:00 am | PDT | UTC-7 hours |
Thurday, 6 July 2023
10:00 am CEST Lyon France | Welcome and review of pre-workshop material |
11:00 am CEST | Course #1: Population PK models, nonlinear mixed-effects models |
12:00 pm CEST | Lunch |
1:15 pm CEST | Course #2 : Monte-Carlo simulations |
2:15 pm CEST | Hands-on #1 : implementing a published model and running a Monte-Carlo simulation with Pmetrics |
3:45 pm CEST | Coffee and tea break |
4:15 pm CEST | Course #3: PK/PD targets, MIC distributions, MIC breakpoints of antimicrobials |
5:00 pm CEST | Course #4: Probability of Target Attainment (PTA), Pharmacodynamic Index (PDI), Cumulative fraction of Response (CFR), and PK/PD breakpoints |
5:30 pm CEST | Close |
Friday, 7 July 2023
8:30 am CEST Lyon, France | Hands-on #2: computing PTA for a basic PK model with Pmetrics |
10:00 am CEST | Coffee and tea break |
10:30 am CEST | Course #5: drug-related and patients-related factors influencing PTA results |
11:15 am CEST | Hands-on #3: factors influencing PTA with Pmetrics |
12:15 pm CEST | Lunch |
1:30 pm CEST | Course #6: using PK/PD for defining standard and high dosage regimens |
2:15 pm CEST | Hands-on #4: identifying effective dosages regimens for continuous and intermittent administration of a beta-lactam with Pmetrics |
3:30 pm CEST | Wrap-up and Q&A |
4:00 pm CEST | Close |
About Pmetrics pharmacometric modelling workshop
This Pmetrics pharmacometrics modelling workshop is suitable for health care practitioners involved in complex drug dosing including clinical pharmacists, infectious diseases physicians and researchers, intensive care physicians, transplant physicians and clinical pharmacologists. It is also suitable for basic researchers including pharmacologists and translational scientists wanting to learn robust methods for the analysis of data from pharmacokinetic studies.
Learning objectives
1. Using the Pmetrics package for R:
- Define pharmacokinetic (PK) and pharmacokinetic/pharmacodynamics(PK/PD) structural models that can be solved analytically and models that require differential equations
- Analyse PK and PK/PD datasets
- Perform basic Monte Carlo simulations for PK and PK/PD analysis
2. With the antimicrobial dosing software tool, users will explore:
- Application of pharmacometric methods to dose individualisation
- Optimise dosing for an individual patient
Venue
University Claude Bernard Lyon 1
Rockefeller campus
8 avenue Rockefeller
69373 Lyon cedex 08
France