Objective 1. The in vitro effect of antimicrobial exposure on the emergence of antimicrobial resistance

Objective 1. Generate new knowledge of the in vitro effect of antimicrobial exposure on the
emergence of antimicrobial resistance for common bacterial pathogens.
Objective 1 explores the effect of antimicrobial exposure on the emergence of resistance for the
clinically important pathogens, Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas
aeruginosa, Klebsiella pneumoniae, Escherichia coli and Acinetobacter baumannii being treated
with common antimicrobials for typical durations of therapy. The HFIM is the most powerful
model for these studies. We are international leaders and the only team with NHMRC funding for
the HFIM (APP1045105, APP1062040 to CI Roberts, Lipman, Bulitta and AI Landersdorfer).