International capacity building reach of CRE REDUCE

24 September 2018


For the past 6 months at UQ CCR, we have had the pleasure of hosting a young erudite researcher from France, whose work ethic and willingness to learn and share learning, inspired us all.  

Mr Clément Boidin is a pharmacy resident working in Hospices Civils de Lyon, France.

Early on in his studies at Lille, France, he became interested in pharmacology and clinical pharmacy and discovered the applications of the pharmacokinetic modeling during his first year as a pharmacy resident at the Claude Bernard University in Lyon. 

Clément started his PhD in 2016 under the supervision of A/Prof. Sylvain Goutelle (Pharmacist) and A/Prof. Arnaud Friggeri (Intensivist) on the different ways to optimise and model antibiotics in critically ill patients. During his PhD, his first project was to use statistical tools including pharmacokinetic modelling to optimise the dosing of amikacin in septic patients.

Clément's visit to the University of Queensland under the supervision of Prof. Jason Roberts was inspired by the goal to enhance his skills in pharmacokinetic modeling. His main objective was to work on the SMARRT study data which focused on 5 commonly used antibiotics (piperacillin/tazobactam, meropenem, vancomycin and linezolid) in critically ill patients under renal replacement therapy (RRT).

After having merged datasets from more than 20 international recruitment sites totalling over 450 patients, Clément used the pharmacokinetic modelling software Pmetrics (developed by the Laboratory of applied pharmacokinetics and bioinformatics) to determine the structural pharmacokinetic model which can best describe the behaviour of these drugs during RRT. These results will be used to develop dosing recommendations for this specific patient group after introduction of covariates of renal function, body descriptors and RRT flow rate.

During his stay in Brisbane, Clément has also nurtured opportunities to collaborate with CRE REDUCE and other visiting researchers such as, for example, in the development of a tobramycin lung diffusion model with Dr Dhanani.

After the completion of his PhD studies, Clément hopes to continue collaborative research projects to optimise antimicrobials use while continuing his practice as a hospital pharmacist.