CRE RESPOND Forum 2024: Developments in reducing antimicrobial resistance through optimised dosing

26 Sep 2024

The Centre of Research Excellence RESPOND welcomed national and international experts in antimicrobial resistance to highlight a large body of research designed to improve treatment of critically ill children and adults in hospitals. The twenty-one speakers, including the CRE RESPOND team and guests, delivered engaging 7-minute presentations covering topics such as pre-clinical and clinical pharmacokinetics studies, and translation of research into changed practice and regulation.

The CRE RESPOND program of work spans over twenty-one projects that seek to optimise and personalise antimicrobial dosing for these at-risk patients.  

The advancements over the last two and a half years include the recently published BLING III work which found that continuous infusion of β-lactam antibiotics results in a decreased all-cause mortality at 90 days in critically ill patients with sepsis. 

Our esteemed international collaborators included Professor Jan de Waele from Ghent University Hospital in Belgium, Professor Mark Gilchrist from the Imperial College Healthcare NHS Trust in the UK and Dr Lowell Ling from The Chinese University of Hong Kong. National collaborators Dr Cornelia Landersdorfer of Monash University, Associate Professor Laurens Manning of University of Western Australia, Professor Andrej Trampuz of the Jamieson Trauma Institute, Dr Adam Irwin from Children’s Hospital Queensland, and Dr Lisa Waddell from the Therapeutic Guidelines Limited joined them.

Their insights and connections with our team and guests were invaluable.

CRE RESPOND has united an expert and targeted network of researchers to enhance clinician decision-making to reduce the burden that sub-optimal antimicrobial dosing has on patients, the healthcare system, and the community. This work will significantly improve the care of patients with infection through the delivery of evidence-based, personalised antimicrobial dosing to reduce the threat of antimicrobial resistance.

A big thank you to everyone who attended, both online and in-person. Special appreciation goes to our resolute team for their ongoing efforts, commitment, and for their valuable contributions to the forum.

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