Dr. Fekade Sime is an NHMRC Emerging Leadership Fellow at the University of Queensland Centre for Clinical Research (UQCCR). His research is dedicated to optimising the stability and infusion regimens of antibiotics for outpatient parenteral antimicrobial therapy (OPAT) programs — a vital area of study as more patients are safely treated outside of hospital settings.
At UQCCR, Dr. Sime leads the In Vitro Infection Model Laboratory, overseeing experimental work for several major projects, including NHMRC-funded studies. He played a key role in establishing a new research capability in Queensland — one of only three laboratories of its kind in Australia — by setting up an advanced hollow fibre infection model. This cutting-edge system replicates human infections in the laboratory, enabling researchers to refine and optimise antibiotic dosing strategies. The model now supports multiple PhD projects under the NHMRC Centre of Research Excellence, CRE RESPOND.
With expertise in the pharmacokinetics and pharmacodynamics of antibiotics, Dr. Sime has earned national and international recognition. He collaborates with leading researchers worldwide and has an impressive publication record of more than 95 peer-reviewed journal articles and three book chapters.
As a committed mentor, Dr. Sime currently supervises six PhD students as principal supervisor. He has also guided seven PhD students to completion (as co-supervisor) and supported the success of eight Honours students.
Through his research, mentorship, and leadership, Dr. Sime is helping to advance antimicrobial optimisation while training the next generation of scientists dedicated to improving antibiotic use.
