Continuous versus intermittent beta-lactams administration in critically ill patients with sepsis not receiving renal replacement therapy.
Administration of beta-lactam antimicrobials by continuous infusion has been proposed as an intervention to improve pharmacokinetic/pharmacodynamic target attainment of these compounds in patients with severe sepsis and septic shock.
This study will be powered to mortality (an important patient-centred outcome). The proposed clinical study will be submitted to the NHMRC for Project Grant funding consideration in 2016 as well as to Canadian and European funding bodies.
Relevant publications
Sanches, Cristina, Alves, Geisa C. S., Farkas, Andras, da Silva, Samuel Dutra, de Castro, Whocely Victor, Chequer, Farah Maria Drummond, Beraldi-Magalhães, Francisco, Magalhães, Igor Rafael dos Santos, Baldoni, André de Oliveira, Chatfield, Mark D., Lipman, Jeffrey, Roberts, Jason A. and Parker, Suzanne L. (2022). Population pharmacokinetic model of piperacillin in critically ill patients and describing interethnic variation using external validation. Antibiotics, 11 (4) 434, 434. doi: 10.3390/antibiotics11040434
Population pharmacokinetics of piperacillin continuous infusion in critically ill patients
Dhaese, Sofie A. M., Roberts, Jason A., Carlier, Mieke, Verstraete, Alain G., Stove, Veronique and De Waele, Jan J. (2017) Population pharmacokinetics of piperacillin continuous infusion in critically ill patients. International Journal of Antimicrobial Agents, 51 4: 594-600. doi:10.1016/j.ijantimicag.2017.12.015
