Workstreams
Workstream 1: Clinical dosing studies
This workstream involves several projects on pharmacokinetic (PK) dosing evaluation of antimicrobials in special patient populations including adult critically ill patients, critically ill paediatric patients, hospitalised patients such as transplant recipients, and patients receiving outpatient antimicrobial therapy
Clinical dosing studies are led by Workstream 1 Lead, Professor Jason Roberts, who is responsible for collating Clinical dosing studies’ status, progress and milestone reports and ensuring they are escalated to the Operations Committee or Steering Committee for consideration and advice.
The objective of clinical dosing studies is to generate new knowledge that to inform robust dosing regimens that achieve therapeutic exposures that can then be tested clinically in the translation projects.
Workstream 1 projects are listed below:
Workstream 1: Clinical dosing studies | Project Lead |
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PNEUDOS Critically ill patient sub-population PK study: Infection site PK and optimised dosing of meropenem, piperacillin, ceftriaxone and penicillin-G in mechanically ventilated patients with ventilator-associated or community-acquired pneumonia (The PNEUDOS Study). | |
SMARRT Critically ill adult patient sub-population PK study: SMARRT Study: SaMpling Antibiotics in Renal Replacement Therapy (RRT). | |
Critically ill adult patient sub-population PK study: multi-centre study of patients receiving life-support | |
Antifungal PK Critically ill adult patient sub-population PK study: Multinational study of antifungal PK | |
Ventriculitis EVDs Critically ill adult patient sub-population PK study: Optimising antimicrobial dosing for ventriculitis associated with external ventricular drains | Prof Jason Roberts |
Critically ill adult patient sub-population PK study: Asia-Pacific regional capacity-building for optimisation of antimicrobial exposure for the treatment of sepsis | |
PIMS Critically ill paediatric patient PK study: Antimicrobial dosing in paediatrics | Prof Jason Roberts |
OPTIONS Critically ill paediatric patient PK study: Gentamicin dosing in neonates (OPTIONS) and Indigenous paediatric patients | Dr Natasha Roberts |
APET PK Critically ill paediatric patient PK study: Dosing in extracorporeal treatments | Prof Jason Roberts |
PK transplant Hospital-based PK study: Antimicrobial dosing in transplant patients | |
PK prophylaxis Hospital-based PK study: Antimicrobial prophylaxis dosing in high-risk surgery | Prof Jason Roberts |
OPAT Community-based study: Optimised parenteral antimicrobial dosing in the community | |
PK complex infection Community-based study: Antimicrobial PK in chronic complex infection | Dr Danny Tsai |
PK in STIs Community-based study: Antimicrobial PK to optimise treatment and reduce antimicrobial resistance for sexually transmitted infections | Prof Jason Roberts |